The recent outbreaks of Methicillin-resistant Staphylococcus aureus (MRSA) among infants in Hong Kong hospitals have raised concerns among healthcare professionals and parents alike. These outbreaks highlight the need for heightened vigilance and effective infection control measures in healthcare facilities. MRSA can cause serious infections in infants, leading to prolonged hospitalizations and potential long-term health complications. To combat the spread of MRSA, hospitals are implementing rigorous infection control measures, including enhanced screening, cleaning and disinfection, contact transmission prevention protocols, and risk assessment. The role of indoor environmental hygiene assessment is also emphasized in reducing MRSA transmission, particularly in high-risk populations such as ICU and NICU patients, immunocompromised patients, and residents of long-term care facilities.